A draw in Asuncion took Uruguay clear at the top of the table, while Venezuela and Colombia earned respective historic wins over Argentina and Bolivia, and Chile bounced back.
In the second round of Group B matches, La Vinotinto’s win over Ecuador took them top of a section also featuring Brazil and Paraguay – both of whom are yet to win.
Cesar Gonzalez's goal was enough to give Venezuela a 1-0 win over Ecuador, leaving La Vinotinto top of Group B and in a great position to reach the Copa America quarter-finals.
Copa Libertadores champions Estudiantes eased into the quarter-finals of this year's competition along with Brazilian giants Flamengo and Cruzeiro.
Attacking midfielder Cesar Gonzalez speaks to FIFA.com about making it as a footballer and Venezuela's hopes of reaching South Africa 2010.
Juan Arango and Giancarlo Maldonado will again form the Venezuelan attack against Brazil, while Roberto Rosales will replace Gerzon Chacon in the side.