CSKA Moscow will be without Keisuke Honda as they face Vladikavkaz, while Zenit St. Petersburg will have to get a result at Terek Grozny if they are to keep alive their hopes of retaining their title.
Leonid Slutsky has a mounting injury list as the CSKA Moscow coach prepares his side for their UEFA Champions League tie with Spanish giants Real Madrid next month.
Zenit St Petersburg climbed to the top of the Russian Premier Liga after a 3-1 win over Amkar Perm, despite CSKA Moscow providing a good display to beat Rubin Kazan 2-0.
Cafu got what proved to be a consolation goal for Anorthosis Famagusta as CSKA Moscow progressed to the group stage of the UEFA Europa League.
FIFA.com looks at the group of players who have risen from the bench to make significant - and often match-winning - impacts at South Africa 2010.
Chile winger Mark Gonzalez believes his side will be facing the most dangerous team in the FIFA World Cup on Friday when they take on Spain.