AFC Champions League winners Guangzhou Evergrande FC defeated CAF Champions League winners Al Alhy SC thanks to two second-half goals from Elkeson and Dario Conca to book a place in Saturday's semi-final.
Seven North African clubs advanced to the last 16 of Africa's biggest club competition, with just one round of head-to-head ties left before the CAF Champions League group stage concludes.
The majority of clubs from nations on the Mediterranean coast posted positive results over the weekend in the continental showpiece's first round, first leg, which featured some dramatic events.
FIFA.com looks at the background to Al Ahly's seventh CAF Champions League success, as the Egyptian club triumphed despite unimaginable adversity following the Port Said tragedy last February.
As Al Ahly and Esperance ST prepare for the first leg of the CAF Champions League final, FIFA.com examines the history between Egyptian and Tunisian sides in the competition.
North African powerhouses Esperance and Al Ahly are hosting delicately balanced last-four contests in the CAF Champions League this weekend with a spot in the continental final at stake.