As well as the serious knee injury suffered by Sami Khedira, Germany coach Joachim Low has also seen the withdrawal of Bayern Munich pair Philipp Lahm and Manuel Neuer ahead of their friendly against England.
Germany midfielder Sami Khedira could miss next summer's FIFA World Cup after suffering a serious knee injury in Friday's friendly draw with Italy in Milan.
FIFA.com takes a closer look at Philipp Lahm, Mesut Ozil, Sami Khedira, Marco Reus and Toni Kroos, Germany's creative quintet who helped Jocahim Low's side qualify for their 16th consecutive FIFA World Cup™.
Sami Khedira, Andre Schurrle and Mesut Ozil were on target as Germany cruised to a 3-0 win over Republic of Ireland that secures their place at Brazil 2014.
If Sweden fail to beat Kazakhstan on Tuesday, Germany can secure passage to the 2014 FIFA World Cup Brazil™ if Joachim Loew's side can claim three points from their encounter with the Faroe Islands.
Ilkay Gundogan is set to miss Germany's upcoming 2014 FIFA World Cup Brazil™ qualifiers against Austria and Faroe Islands, following a back injury sustained in the recent friendly against Paraguay.