Arsenal and Manchester United played out a goalless draw, while the Gunners' close rivals Tottenham Hotspur cruised to a 4-0 victory over Newcastle United. Elsewhere, Liverpool left it late to win 3-2 at bottom side Fulham.
Eden Hazard scored a hat-trick as Chelsea capitalised on Arsenal's crushing defeat at Liverpool by beating Newcastle United 3-0 to claim top spot in the Premier League, while Manchester City drew at Norwich City.
Oscar scored a sublime free-kick to send Chelsea into the fifth round of the FA Cup with a 1-0 win over English Premier League rivals Stoke City, while Sheffield United battled to a 1-1 draw with Fulham, forcing a fourth round replay.
Manchester City leapt Chelsea to go top of the English Premier League after defeating Newcastle 2-0 on the road, while Liverpool beat Stoke City 5-3 in an enthralling encounter at the Britannia Stadium.
Liverpool spend at least the weekend at the top of the Premier League after a 3-1 win over Cardiff City, while there were wins for both Manchester clubs, with City having to recover from being pegged back by Fulham to win 4-2.
Two shock results headlined the English Premier League with Newcastle United winning at Old Trafford for the first time in 41 years and Stoke City beating Chelsea 3-2 at home.