Adriano scored the only goal as Barcelona laboured to a 1-0 victory over Malaga without the injured Lionel Messi, while Atletico Madrid thumped Rayo Vallecano 5-0 and Levante and Sevilla played out a goalless draw.
Atletico Madrid are set to be without midfielder Tiago for the foreseeable future after he suffered a broken arm during the Copa del Rey semi-final against Sevilla.
Atletico Madrid maintained their perfect record at the Vicente Calderon with a 2-0 win over Real Zaragoza, while Real Betis kept their European hopes alive with a comfortable victory over Levante.
Radamel Falcao was on target three times as Atletico Madrid thrashed La Liga rivals Athletic Bilbao 4-0, with Tiago adding the final goal for Diego Simeone's side.
In our regular Sunday feature, FIFA.com presents you with some of the biggest names in football who will be celebrating their birthdays over the coming week.
Tiago has returned to Atletico Madrid, where he spent last season on loan, signing a two-year deal after his contract at Juventus was terminated by mutual consent.