Bayern Munich underlined their Bundesliga superiority once again, coming from behind to beat Wolfsburg 6-1, while Schalke won 4-0 at home to Hoffenheim thanks to a Klaas-Jan Huntelaar hat-trick.
Real Madrid routed Schalke 6-1 with braces from Karim Benzema, Gareth Bale and Cristiano Ronaldo, while Chelsea drew Galatasaray 1-1 in Turkey in UEFA Champions League last-16 first-leg matches.
Bayern Munich warmed up for their UEFA Champions League last 16, first-leg clash at Arsenal by trouncing Freiburg 4-0 to stretch their Bundesliga lead to 16 points, while Leverkusen slumped to defeat at home to Schalke.
Schalke returned from the winter break in style with a 3-0 win over Hamburg, which saw the German Bundesliga side move fifth, while Eintracht Braunschweig battled Werder Bremen to a goalless draw.
Klaas-Jan Huntelaar is likely out of action for Schalke until January due to knee ligament damage, the club confirmed Thursday, though the Dutch international is seeking a second opinion.
Schalke coach Jens Keller and new star Kevin-Prince Boateng have both spoken positively ahead of their opening UEFA Champions League match against Steaua Bucharest, with Bayern Munich to follow in the German Bundesliga.