Atletico Madrid striker Diego Costa could make his debut for Spain after being named in Vicente del Bosque's 22-man squad for the FIFA World Cup holders' home friendly against Italy.
Chelsea go into Saturday's derby against Fulham protecting a one-point lead at the summit while second-placed Arsenal face a tricky challenge at Stoke, with the pair looking to move clear of Manchester City who play in the League Cup final.
Jose Mourinho says his Chelsea side missed the chance to take a stranglehold on their UEFA Champions League last-16 against Galatasaray, while rival Roberto Mancini says his side are now a "40 per cent" chance to progress.
Real Madrid routed Schalke 6-1 with braces from Karim Benzema, Gareth Bale and Cristiano Ronaldo, while Chelsea drew Galatasaray 1-1 in Turkey in UEFA Champions League last-16 first-leg matches.
Jose Mourinho insists Chelsea's English Premier League title chances lie in the hands of rivals Arsenal and Manchester City, despite the Blues recently overcoming Manuel Pellegrini's men at the Etihad Stadium.
As two of England's most seasoned top flight campaigners, Liverpool and Arsenal have battled in some memorable clashes. With two more in the space of eight days looming, FIFA.com recalls five of their best.