The 31-year-old, who succeeded Jens Lehmann as the country's first-choice custodian after UEFA EURO 2008, broke the scaphoid bone in his hand in training on Wednesday afternoon and the injury was confirmed on Thursday.
It means either Werder Bremen's Tim Wiese or Bayer Leverkusen's Rene Adler will make their debut on Saturday.
Play and win
Keen to test your football knowledge and expertise? Sign up for the FIFA.com Club today and play the McDonald's FIFA World Cup Fantasy and the McDonald's FIFA World Cup Predictor games. With great prizes, including trips to South Africa 2010, on offer, what are you waiting for?