Central defender and captain Diego Lugano, who has a right ankle injury, is also doubtful for the game in Cape Town.
Medical staff said earlier on Saturday that defender Jorge Fucile was still under observation after suffering an awkward fall during the quarter-final win over Ghana on Friday.
"He is okay. He suffered concussion after bumping his head, neck and shoulder but he did not lose consciousness. But we have to take care of his state of health," team doctor Alberto Pan said.
A booking means that Fucile will miss the Dutch encounter anyway through suspension, as will striker Luis Suarez, who was given a straight red for handling on the line right at the death.