Coach Joachim Low has already been deprived of five players for the tournament, with Schalke defender Heiko Westermann the latest to be ruled out.
The withdrawal of Westermann, who broke his foot during Saturday's 3-0 friendly win over Hungary in Budapest, comes after injury had put paid to the hopes of goalkeeper Rene Adler, Simon Rolfes, Christian Trasch and, most importantly, skipper Michael Ballack.
Those injuries will hardly make Germany's task any easier - they are in a tough-looking group alongside Serbia, Ghana and Australia - but Lahm still believes the squad is strong enough to make an impact in South Africa.
"That we have lost players who are enormously important for us is a shame," said the Bayern Munich full-back, chosen as Low's captain in place of Ballack, at a press conference today.
"But we still have a top squad which can go far."