Maradona's men currently hold fourth spot in the South American qualifying zone - the final position which would guarantee a place in South Africa next summer - with four games remaining. With Ecuador just two points behind, the pressure is on Argentina to get at least a point against the Brazilians.
Playing for a draw is not in Maradona's thinking, however. "We have to play in Brazil's box. We can't let them breathe," said the former World Cup winner.
Maradona requested to have the game moved from River Plate's home ground to a more intimate venue in Rosario City. And the fans' support, coupled with an attacking line-up, has left the hosts' coach confident of success.
"We'll attack them down the wings with Maxi Rodriguez and Jesus Datolo, down the centre with Juan Sebastian Veron, with Lionel Messi and Carlos Tevez creating havoc, with Javier Zanetti moving forward from the back," he said. "The free-kicks and corner-kicks can also be good for us. We have a lot of options, we have to play our best game against a great team."
Brazil are in far better shape than Argentina. They currently lead the standings by a point from Chile and a win against Argentina could see them clinch a place in South Africa, providing other results also go their way this weekend.
Brazil's Real Madrid playmaker Kaka believes having the points in the bag could give them a psychological edge tomorrow. "It will be a very tense duel. They will have much more pressure on them than us and we have to use that in our favour," said the former AC Milan star.
"We need to show patience and be clever to play in a stadium that will be new for them too. If I was in their position, with such troubles to qualify for the World Cup, it would be impossible for me to sleep at night."
Manchester City star Robinho is expecting the home side to adopt a rough-and-tumble approach. "They will hit us, that's normal and they always do it. We will play hard too, but with the ball," he said. "They want to create a war-like atmosphere, but we have to play football and score goals."