Germany top Group 4 with nearest rivals Russia four points behind, but Low knows his side can ill-afford to drop points either on Saturday or on 1 April against Wales in Cardiff before they travel to Moscow in October.
Having recovered from a broken hand, Hanover's Robert, 31, is back in goal while an ankle injury to Miroslav Klose means Gomez will partner Lukas Podolski up front. "Robert has showed good form in recent weeks and we trust him," said Low in Wednesday's press conference.
With Leverkusen goalkeeper Rene Adler nursing an elbow injury, Enke will keep his place to face the Welsh in Cardiff four days later unless he picks up an injury. Meanwhile, Leverkusen striker Stefan Kiessling passed a fitness test on Thursday and looks set to be included on the bench.
Hamburg winger Piotr Trochowski is out with a knee injury, so Gomez is expected to start having scored seven goals in his last eight league games, despite a poor performance at UEFA EURO 2008 last June.