The 30-year-old, Romania's third all-time scorer with 29 goals, said that a draw would not be good enough against a side that presently tops Group 7 with nine points, despite the fact the Romanians - on four points - have a game in hand.
"We cannot just come away with a draw against Serbia," said Mutu. "This match is vital because if we don't win, we won't have a chance of qualifying," added Mutu, who also said that they must take three points off Austria on 1 April.
The Fiorentina marksman claimed Serbia had an advantage because their players played in tougher championships than most of the Romanian squad and called on his compatriots to motivate themselves so that they would not allow this to be replayed out on the pitch.
"We have shown before that we can play as well as stronger teams than us such as against France (a 2-2 draw in their World Cup qualifier last October) and Holland (a 1-0 victory in a Euro 2008 qualifier)," said Mutu, who is just six goals short of Romania's leading all-time scorer Gheorghe Hagi.