Big cities, big games
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A clutch of Europe's biggest teams safely negotiated their passage to the UEFA Champions League knockout stages in midweek, and will now be looking to maintain the momentum when they resume domestic duty this weekend. The biggest match takes place in London, where Chelsea entertain Arsenal, with the Manchester derby taking place further north. FIFA.com previews the forthcoming action across the continent.

English Premier League: Mouth-watering super Sunday in prospect
The weekend fixtures in England include two truly mouth-watering games. First, City will host United in the Manchester derby. Mark Hughes's side are 11th, while the Red Devils have inched up to third with a series of improved results in recent weeks. The pressure is definitely on Robinho and Co, who are only three points above the drop zone.

Later on Sunday afternoon, fifth-placed Arsenal visit leaders Chelsea. Arsene Wenger's Gunners have lost their last two league matches, whereas the Blues have gone five games without defeat, without conceding a goal in the process.

The question: Who will emerge with the bragging rights from the Manchester derby: Robinho and City or Cristiano Ronaldo and United?
The big game: Chelsea-Arsenal, Sunday 30 November, 17.00 CET, Stamford Bridge
The quote: "We want to fight our way back into the title race, so it's a game we have to win. But we're not putting ourselves under too much pressure. We're confident ahead of the game," Cesc Fabregas, Arsenal player.

Italian Serie A: Inter vow to make amends
After a shock 1-0 defeat at home to Panathinaikos in the Champions League, Inter Milan are seeking to bounce back on Sunday when fourth-placed Napoli visit the San Siro. AC Milan, trailing Jose Mourinho’s men by three points, face a less daunting task on paper - a trip to Palermo - although the team in tenth will be quietly confident of an upset. Third-placed Juventus, meanwhile, are at home to struggling Reggina.

A fixture full of intriguing possibilities takes place in the Italian capital, where Roma, still languishing in an unaccustomed 15th, meet Fiorentina, just a point off a top-four place.

The question: Can Roma extend a run of three games without defeat when they meet Fiorentina, thus taking another step away from the lower reaches of Serie A?
The big game: Inter Milan-Napoli, Sunday 30 November, 15.00 CET, San Siro
The quote: "After this result [the 1-0 defeat to Panathinaikos] we have to come out with the right attitude at our home ground against Napoli and deliver a very different performance," Jose Mourinho, Inter Milan coach

French Ligue 1: Manageable tasks for Lyon and Nice
Lyon have already opened up a five-point gap over runners-up Nice in Ligue 1. The lead seems unlikely to shrink on Matchday 16, with Lyon at home to relegation-threatened Valenciennes and Nice entertaining 11th-placed Grenoble.

The big game of the weekend takes place on Sunday evening in Brittany, where fourth-placed Rennes meet Paris Saint-Germain, who lie fifth. The clubs are currently level on points in the battle for places in Europe next term.

The question: Can the underdogs from Valenciennes and Grenoble cause an upset against the top two?
The big game: Rennes-Paris Saint-Germain, Sunday 30 November, 21.00 CET, Stade de la Route de Lorient
The quote: "I’ve realised what my problem was at the start of the season – I lacked aggression. To play well, I need to be angry," Cris, Lyon defender.

German Bundesliga: Rivals square off in Leverkusen
The BayArena in Leverkusen provides the stage for the big game on Matchday 15, when second-placed Bayer Leverkusen entertain Bayern Munich, who are third. Both clubs will go all out for victory in an effort to chase down leaders Hoffenheim, who are at home to 14th-placed Arminia Bielefeld.

The Sunday fixtures offer two further potentially engrossing matches. Stuttgart, down in a disappointing 11th and with Markus Babbel in a caretaker role at the helm, entertain seventh-placed Schalke, whose season is also failing to live up to expectations. Elsewhere, a battle of UEFA Cup contenders pits Wolfsburg against Borussia Dortmund.

The question: Can holders Bayern Munich maintain their impressive unbeaten run? Jurgen Klinsmann’s side have not lost in all competitions since a 1-0 defeat in Hanover on 27 September.
The big game: Bayer Leverkusen-Bayern Munich, Saturday 29 November, 15.30 CET, BayArena
The quote: "They’re making it easy for me. I’m really confident at the moment," Vedad Ibisevic of Hoffenheim, the league’s leading scorer with 16 goals and seven assists, praises his team-mates.

Spanish La Liga: Top three on their travels
The top three in Spain are all away from home this weekend, although the big guns face differing degrees of difficulty on their travels. Leaders Barcelona, whose solitary defeat this term came on the opening day, face the hardest task against fifth-placed Sevilla, who are battling to break into the Champions League qualifying places.

Real Madrid make the short trip to mid-table Getafe, and Villarreal visit bottom team Recreativo Huelva. Valencia, in fourth, will probably need to beat Real Betis to stay in touch with the top three.

The question: Can Sevilla inflict a second defeat of the season on Barcelona?
The big game:  Sevilla-Barcelona, Saturday 29 November, 22.00 CET, Ramon Sanchez Pizjuan stadium
The quote: "After our draw with Barcelona, the game against Real Madrid is really special for us," Victor Munoz, Getafe coach

Elsewhere
In Poland, promoted Polonia Warsaw head the Ekstraklasa standings after 15 games, and will aim to add another three points to their tally at home to Arka Gdynia. The three-strong pursuing pack of Lech Posen, Legia Warsaw and Wisla Krakow are all away from home, and all under pressure.

The Turkish league programme features one of the great Istanbul derby fixtures. Fenerbahce, currently off the pace in sixth spot in the Super Lig, entertain second-placed Besiktas. Leaders Trabzonspor aim to hold on to top spot when they travel to cup holders Kayserispor.