Sevilla defender Antonio Puerta's condition has worsened since he suffered a heart attack during a Spanish league match on Saturday, the hospital where he was admitted said Tuesday.

The 22-year-old Spanish international is in a "very critical" condition in the intensive care unit of Seville's Virgen del Rocio hospital where he is hooked up to life support machine, the hospital said in a statement.

"The clinical evolution of the patient in unfavourable," it said, adding the prolonged cardiac arrest had damaged Puerta's organs and led to a lack of oxygen to the brain.

Puerta collapsed after half an hour of Sevilla's 4-1 win over Getafe on the opening day of the Spanish season.

He was able to walk gingerly to the dressing rooms where he collapsed a second time before being taken to hospital.