Two goals from Hernan Rodrigo Lopez helped Paraguayan side Libertad qualify for the second stage of the Copa Sudamericana with a 3-0 home win over Bolivia's Nacional Potosi on Wednesday.
The Uruguayan striker netted a fourth-minute penalty and scored again in the 40th minute before Antonio Bareiro's late goal clinched a 3-1 aggregate triumph.
"I'm very happy because we finally scored the goals we deserved and they helped us progress," Libertad head coach Pedro Sarabia said in Asuncion.
Libertad's next opponents will be Ecuadorian giants Barcelona, who eliminated Peru's Alianza Lima with a goalless draw sealing a 3-0 aggregate win.
Uruguayan side River Plate booked a berth in the next phase by beating Chilean giants Universidad Catolica 3-0 to confirm a 4-0 aggregate victory. Michael Santos, who had scored the winner in the first leg, opened the scoring 24 minutes after the interval and late goals from Santiago Garcia and Christian Techera made certain.
Catolica duo Alfonso Parot and Dario Botinelli were sent off in the closing stages and River Plate will play Emelec of Ecuador in the next round.
General Diaz of Paraguay qualified with a 2-2 draw away to Chile's Cobresal to win 4-3 on aggregate - but to do so, they had to hang on with only eight men. Team-mates Angel Vera and Gustavo Toranzo were sent off for fighting in the first half and Cristian Sosa followed in the second half.
Roberto Gamarra and Victor Genes had given General Diaz a 2-1 lead on the night before they lost their discipline, and despite their dwindling numbers their opponents could only add Johan Fuentes' 86th-minute goal to a first-half strike from Matias Donoso. General Diaz next face Colombian giants Atletico Nacional, who saw off Deportivo La Guaira of Venezuela 1-0 thanks to a 53rd-minute goal by Luis Carlos Ruiz. It was a 2-1 aggregate triumph for Atletico, who had Alexander Mejia sent off.
Independiente's Armando Solis and Trujillanos' Sergio Alvarez scored the goals in the closing moments, with the visitors having played a man light since Jarol Herrera's first-minute dismissal.
The second stage began with Brazilian side Bahia claiming a surprise 2-0 win at compatriots Internacional. A Lucas Fonseca header in the 42nd minute and another by Diego Macedo seconds after the break gave Gilson Kleina's side a promising position to take into the second leg next Thursday in Salvador.