Holders Atletico Madrid set up a mouthwatering Copa del Rey semi-final with city rivals Real Madrid after beating Athletic Bilbao 2-1 to win 3-1 on aggregate.
Barcelona also assured their place in the last four with a 5-1 victory over Levante at the Camp Nou to seal a 9-2 rout on aggregate.
In Bilbao, Aritz Aduriz had powered the hosts into a deserved lead four minutes before half-time and Athletic were only denied a bigger advantage at the break by two outstanding saves from Thibaut Courtois.
However, Atletico regrouped at the break and levelled ten minutes after the restart when Raul Garcia smashed home Emiliano Insua's cross.
Diego Costa sealed their passage into the last four in the final stages as he slotted home his first goal of 2014 on the counter-attack to inflict Athletic Bilbao's first ever defeat at their San Mames ground, which they have used since the start of the season.
Atletico will travel to the Santiago Bernabeu, where they beat Real 2-1 in last year's final, for the first leg of the semi-final next week with the return to come at the Vicente Calderon the following week.
"In the first 30 minutes we were in control of the tie, if not the match," Atletico boss Diego Simeone said.
"From then until half-time they had a great end to the half, but we came out strong in the second-half and got the goal which gave us confidence and strength."
Simeone's men will now face Real three times in little over three weeks in league and Cup.
"This season we will play four more games against Barcelona and Real Madrid and that is good because it tests you more, but you also lose the fear of playing in those games."
Sergi Roberto's early own goal had given the visitors some hope of an improbable comeback from last week's 4-1 defeat.
Two goals in quick succession after the break from close range by Alexis Sanchez extended the hosts lead.
Cesc Fabregas rounded off the scoring as his low effort beat Javi Jimenez at his near post 21 minutes from time.