Aston Villa manager Paul Lambert will have no need to worry about the FA Cup being a distraction this season after League One Sheffield United dumped his side out in the upset of the third round with a 2-1 win.
Lambert had said earlier this week the cup was something he could do without and his side fell behind at Villa Park thanks to Jamie Murphy's deflected strike for the Blades. Nicklas Helenius levelled for Villa but Ryan Flynn's superb strike gave United a 2-1 victory and a place in the fourth round.
Championship Leeds United were another side to be on the receiving end of an upset as they lost 2-0 at Rochdale. Scott Hogan and Ian Henderson got the goals at Spotland as the League Two side enjoyed a memorable triumph.
Cardiff City manager Ole Gunnar Solskjaer made a winning start to his reign as his side came from behind to win 2-1 at Newcastle United.
Papiss Cisse had put the Magpies ahead at St James' Park but substitutes Craig Noone and Fraizer Campbell hit back for the Bluebirds.
Non-league Macclesfield earned themselves a replay as they drew 1-1 with Championship Sheffield Wednesday. Reda Johnson had put the Owls ahead at Moss Rose but Steve Williams' strike earned the hosts the chance to do it all again at Hillsborough.
City battle to draw with Blackburn
Last season's beaten FA Cup finalists Manchester City tasted fresh disappointment in the competition on Saturday when they drew 1-1 at second-tier Blackburn Rovers in the third round.
Stunned by Wigan Athletic in last year's final, City took the lead at Ewood Park through an Alvaro Negredo goal on the stroke of half-time, only for Scott Dann to equalise early in the second period.
In the day's two other all-Premier League ties, goals from Dwight Gayle and Marouane Chamakh gave Crystal Palace a 2-0 win at West Bromwich Albion and Fulham drew 1-1 at Norwich City.
Everton crushed Championship high-fliers Queens Park Rangers 4-0, with Nikica Jelavic claiming a brace, while Southampton edged Burnley 4-3 in an entertaining game at St Mary's.
Hull City won 2-0 at Middlesbrough and Stoke City defeated Championship leaders Leicester City 2-1.
Wigan's trophy defence began in uncertain fashion as they were held to a 3-3 draw by third-tier Milton Keynes Dons.
Goals from Roger Espinoza and Jordi Gomez put Wigan 2-0 up, but Ben Reeves struck twice in two minutes to draw MK Dons level and, after Callum McManaman restored the hosts' lead, Patrick Bamford scrambled home a late equaliser.
Bolton Wanderers belatedly exacted revenge for their 4-3 loss to Blackpool in the 1953 final by beating their Championship rivals 2-1.