Tottenham Hotspur edged Hull City 8-7 in a tense penalty shoot-out to reach the English League Cup quarter-finals, while Manchester City overcame Newcastle United after extra time.
Hull had lost 1-0 to Spurs in the English Premier League on Sunday and they came within a whisker of exacting swift revenge on their return to White Hart Lane.
Icelandic midfielder Gylfi Sigurdsson was one of the players brought into the Spurs team and he made a stunning impact in the 16th minute, flummoxing his marker with a neat drag-back and then arrowing a sumptuous shot home from 25 yards.
Second-choice goalkeeper Brad Friedel made a less favourable impression, however, gifting Hull an equaliser in the 53rd minute.
Liam Rosenior's low cross from the right was hooked back across goal by the sliding Curtis Davies and Friedel inadvertently fumbled the ball into his own net for an own goal.
Spurs saw 20-year-old midfielder Harry Kane rattle the woodwork from 20 yards in stoppage time, but it was Hull who struck first in extra time, with Paul McShane heading home from a George Boyd corner.
Kane would not be discouraged, however, and he drilled home a 108th-minute equaliser to make it 2-2 and send the game to penalties.
Aaron McLean missed for Hull before Spurs' record signing Erik Lamela fluffed his lines for the hosts, but Friedel had the final say, saving with his legs from Ahmed Elmohamady to secure a nail-biting win.
City made ten changes to the team beaten 2-1 at Chelsea on Sunday, with Javi Garcia the only player to keep his place, while Newcastle manager Alan Pardew brought five new players into his starting line-up.
There was an early blow for the visitors when Montenegrin forward Stevan Jovetic had to go off in the tenth minute following a challenge by Mike Williamson, with Negredo coming on in his place.
Newcastle enjoyed the best of the first half, but Shola Ameobi was thwarted by City goalkeeper Costel Pantilimon and had a goal ruled out for offside, while Vurnon Anita volleyed just wide.
City upped the tempo after the interval, with James Milner and Negredo both going close, and it was Negredo who broke the deadlock in the ninth minute of extra time, sweeping home a low cross from Dzeko.
Dzeko got on the scoresheet himself moments later, skirting Krul and rolling the ball home to rubber-stamp City's place in the last eight for the fourth time in seven years.
The draw for the quarter-finals handed Manchester United an away game at Stoke City, who were beaten 3-2 at Old Trafford in the league on Saturday.
Chelsea will visit the victors of the one remaining fourth-round tie between Sunderland and Southampton, which is due to be played next Wednesday.