UEFA Champions League holders Bayern Munich joined Real Madrid and Paris Saint-Germain in emerging from the second round of group games with comfortable wins on Wednesday while the two clubs from Manchester endured differing fates.
David Moyes' United, after their worst start to a domestic campaign in 24 years, were held to a dour 1-1 draw by Shakhtar Donetsk in a game that went ahead without injured Wayne Rooney. The stalemate, after Danny Welbeck's early opener was cancelled out by Taison 14 minutes from time, left United level with Shakhtar at the top of Group A, after Bayer Leverkusen beat Real Sociedad 2-1.
United's veteran Welsh international Ryan Giggs came on to create history in the second half to overtake previous record holder Raul with his 145th appearance in Europe's top club competition.
Back in Manchester, at the Etihad stadium, City were humbled 3-1 by brilliant Bayern, playing in England for the first time since claiming the trophy at Wembley last season, in a clash that reunited City's manager Manuel Pellegrini with Pep Guardiola. The pair are old foes from Spain, when they occupied the dugouts at Real Madrid and Barcelona respectively in 2009-10.
It was Guradiola who came away with the bragging rights after goals from Franck Ribery, Thomas Mueller and Arjen Robben - Alvaro Negredo getting a late consolation for City - which pushed the German giants onto six points and firmly in command of Group D. City lie second on three points with CSKA Moscow, 3-2 winners over Viktoria Plzen, in third on goal difference.
Mancini's endures enthralling debut
Pellegrini's predecessor at City, Roberto Mancini, enjoyed a baptism of fire in his first game just 48 hours after being appointed coach of Galatasaray. Didier Drogba gave Mancini the perfect start, putting the Italian's new Turkish club into the lead - but Juventus hit back with a late double from Arturo Vidal's penalty and Fabio Quagliarella before substitute Umut Bulut bagged the equaliser two minutes from time.
Galatasaray, who are bottom of Group B, had been hammered 6-1 by table toppers Real Madrid last time out and Real were at it again, drubbing FC Copenhagen 4-0 at the Bernabeu with doubles from Cristiano Ronaldo and Angel di Maria.
The nine-time champions of Europe are well on course for the last 16, four points ahead of Juve with the Italians next up to visit Real's stronghold.
Paris Saint-Germain are sitting pretty on six points and occupying the Group C summit after their 3-0 win over shell-shocked Benfica at the Parc des Princes. The Parisians indicated that they are genuine title contenders with a stunning first-half display thanks to superbly-worked goals by Zlatan Ibrahimovic, who grabbed a brace, and Marquinhos.
Benfica tread water on three points, ahead only on goal difference from Olympiacos who defeated Anderlecht by an identical scoreline.