Bakkali, who only made his senior debut for PSV in the club's UEFA Champions League third qualifying round, first leg against Belgian side Zulte-Waregem last week, was one of five strikers called up by Wilmots.
Standard Liege captain Jelle Van Damme was recalled after a six-month absence, the defender last appearing for his country in a 2-1 victory over Slovakia in February.
The squad features 11 Premier League-based players, including Chelsea trio Eden Hazard, Kevin De Bruyne and Romelu Lukaku, Manchester City captain Vincent Kompany, Everton midfielder Marouane Fellaini and Aston Villa striker Christian Benteke.
However, there was no place for injured Arsenal defender Thomas Vermaelen, nor Torino goalkeeper Jean-Francois Gillet, who is serving a three-year, seven-month ban for his alleged involvement in match-fixing while at former club Bari.
Goalkeepers: Koen Casteels (Hoffenheim/GER), Thibaut Courtois (Atletico Madrid/ESP), Simon Mignolet (Liverpool/ENG)
Defenders: Toby Alderweireld (Ajax/NED), Laurent Ciman (Standard), Guillaume Gillet (Anderlecht), Vincent Kompany (Manchester City/ENG), Nicolas Lombaerts (Zenit Saint-Petersburg/RUS), Sebastien Pocognoli (Hannover/GER), Daniel Van Buyten (Bayern Munich/GER), Jelle Van Damme (Standard), Jan Vertonghen (Tottenham/ENG)
Midfielders: Nacer Chadli (Tottenham/ENG), Kevin De Bruyne (Chelsea/ENG), Steven Defour (Porto/POR), Moussa Dembele (Tottenham/ENG), Marouane Fellaini (Everton/ENG), Eden Hazard (Chelsea/ENG), Timmy Simons (Club Brugge), Axel Witsel (Zenit Saint-Petersburg/RUS),
Forwards: Zakaria Bakkali (PSV Eindhoven/NED), Christian Benteke (Aston Villa/ENG), Romelu Lukaku (Chelsea/ENG), Dries Mertens (Napoli/ITA), Kevin Mirallas (Everton/ENG)