PSV Eindhoven opened up a 2-0 first-leg advantage in their UEFA Champions League third qualifying round tie against Belgian side Zulte-Waregem.
The Eredivisie side were kept at bay for an hour before Memphis Depay opened the scoring, and fellow teenager Jurgen Locadia then doubled the lead in the 75th minute.
Ligue 1 side Lyon were made to work hard for a 1-0 first-leg lead over Swiss side Grasshoppers, defender Milan Bisevac with the only goal midway through the second half.
Basel were 1-0 winners at home to Maccabi Tel Aviv, Valentin Stocker with the only goal six minutes before half-time.
Steaua Bucharest will be confident of progressing after a 2-0 win in their away leg against Dinamo Tbilisi, 19-year-old substitute Gabriel Iancu with both goals.
Dinamo Zagreb were made to wait until the 89th minute before Ante Rukavina scored the only goal of the game to give them a lead to take to Moldova for their second leg against Sheriff Tiraspol.
Marko Devic scored both goals, the first a penalty, in Metalist Kharkiv's 2-0 away win over PAOK Salonika while Marian Cisovsky netted a hat-trick as Plzen won 4-0 away to Nomme Kalju.
Austria Vienna won only 1-0 against Iceland's FH Hafnafjordur but Kazakhstan's Shakhter Karagandy took a commanding 3-0 lead against Skenderbeu of Albania.