The 31-year-old forward, who has made a strong return to form this month with the Americans in the CONCACAF Gold Cup, was selected by MLS commissioner Don Garber to replace Republic of Ireland star and Los Angeles Galaxy team-mate Robbie Keane, who is out with a left hip flexor strain, in the MLS lineup.
Donovan, in his 13th MLS season and 13th consecutive MLS All-Star Game, was part of a record-tying fifth MLS championship club last December when he helped the Galaxy win the MLS crown.
He then took a four-month break from the sport, needing to rest his mind and body. After returning to the Galaxy, Donovan scored three goals and set up six others in 13 matches for the Galaxy but he was not called into Jurgen Klinsmann's team for CONCACAF FIFA World Cup™ qualifying matches.
He was given a chance to show what he could do this month on the national team in the Gold Cup and has responded with seven goals and key passes to set up seven more over six games as the unbeaten Americans advanced to Sunday's title match against Panama.
"Landon is a great addition to the MLS All-Star team," said All-Star coach Peter Vermes. "Obviously his form is fantastic right now and his impact and representation of MLS throughout his career is immeasurable."