Gonzalo Bueno scored twice as Uruguayan giants Nacional crushed Mexican side Toluca 4-0 to secure their place in the last 16 of the Copa Libertadores on Thursday.
Bueno opened the scoring in the 10th minute after a defensive blunder from Edgar Duenas, firing past goalkeeper Alfredo Talavera, and midfielder Israel Damonte doubled the lead before half-time.
A penalty from Ivan Alonso made it 3-0 and Bueno netted the fourth.
The result ensured Nacional will finish in the top two in Group One, and it also meant Boca Juniors also advance.
With one round of games to go, Nacional lead the group with 10 points, with Boca now second on nine, with Toluca on five and Ecuadorian outfit Barcelona last on three.
Paraguayans Olimpia also advanced thanks to a 1-0 win against Universidad de Chile, secured by Richard Ortiz's strike in the 50th minute.
Argentinian club Newell's Old Boys edged closer to joining Olimpia in advancing from Group Seven after a 3-1 win over Venezuelan side Deportivo Lara.
Ignacio Scocco scored twice, with the other Newell's goal coming in the early stages from Pablo Perez, who netted from outside the penalty area. Edgar Perez Greco pulled one back before Scocco's second, a stunning solo goal that saw him skip through several challenges, made the points safe.
Scocco said: "When things got difficult, luckily I managed to extend the lead."
Newell's stand second in the group, three points ahead of Universidad de Chile who are their opponents in the last round of games. Lara are at the foot of the group and resigned to missing out on the last 16.
Bolivia's The Strongest celebrated a 2-1 win over Brazilian side Sao Paulo to keep their hopes alive of progressing from Group Three.
Nelvin Soliz had his early long-range strike wiped out by a penalty from Sao Paulo goalkeeper Rogerio Ceni, their regular spot-kick taker. But with the hour mark approaching Ceni then failed to grasp an ambitious shot from outside the penalty area from Ernesto Cristaldo, letting it creep past him for the winner.
Atletico Mineiro have won the group after five wins, with The Strongest now second on six points, two ahead of Sao Paulo and Argentinian side Arsenal.