Brazilian giants Corinthians claimed a 2-0 win over Colombian side Millonarios in their Pacaembu stadium on Wednesday.
Supporters were barred after previous crowd issues, but despite the quiet in the ground, it took Jose Guerrero only nine minutes to open the scoring, pouncing on a loose ball in the box to fire home.
The hosts continued to dominate the game, but Alexandre Pato (twice), Paulinho, Renato Augusto and Guerrero all missed chances.
Early in the second half the Brazilians finally doubled their advantage and secured the victory: Ralf crossed for Pato and this time the former AC Milan forward made no mistake.
Another Brazilian giant, Fluminense, came back to claim a 2-1 victory over Huachipato in Chile to lead Group Eight.
The first half was very poor, with few goal chances, the best one wasted by Wellington Nem for the visitors when he hit the crossbar.
But just before the break, defender Leandro Euzebio made a mistake allowing Huachipato's Braian Rodriguez in and the striker showed no mercy.
Fluminense were rejuvenated in the second half and in the 66th minute Fred found Wellington Nem, who this time made no mistake and equalised with a powerful shot. And 10 minutes later Wagner jumped off the bench and almost immediately made it 2-1.
Meanwhile, in a Group One match in Ecuador, Argentinian side Boca Juniors claimed a key win over Barcelona, 2-1, having lost their first home game against Mexico's Toluca.
After a goalless first half, the Argentinians opened the scoring through Juan Manuel Martinez in the 58th minute, after a header from Lucas Viatri, and when Barcelona were trying to recover, Claudio Perez made it 2-0 with a header four minutes later.
The Ecuadorians narrowed the gap in the 92nd minute, after a needless foul by Clemente Rodriguez into the box, with Michael Arroyo scoring the penalty kick.