Premier League champions Manchester City face a tough challenge when they travel to Stoke City in the FA Cup fourth round. Roberto Mancini's side are seeking FA Cup success for the second time in three years after beating their opponents 1-0 in the 2011 final.
Midfielder James Milner said: "It should be a really good old fashioned FA Cup tie but we're confident, going there on the back of five straight wins. The Britannia Stadium is not the easiest of venues to go to but if we can quiet the home crowd early on then so much the better."
"The fact that we're taking more than 4,000 fans is really important because the Stoke fans make a lot of noise, but our supporters are brilliant and will give as good as they get when it comes to creating an atmosphere."
Stoke manager Tony Pulis is also aware of how big a role the fans can make in the outcome of the match. "We have to play to our maximum, and the crowd have to be at their maximum, for us to get a result on Saturday."
In other fourth round fixtures, Manchester United host Fulham. Alex Ferguson's men have not won the competition since 2007 and equally shocking is the fact that the majority of his side have failed to win the competition in their careers.
Martin Jol will lead his Fulham side to Old Trafford in the search of an FA Cup shock. "Hopefully we can come up with a surprise against Man United in the Cup," said the Dutchman.
Arsenal, who travel to Brighton and Hove Albion, have already been the victims of a shock this season when they lost to Bradford City in the League Cup. However, the London club is showing signs of improvement after their 5-1 victory against West Ham United in the league.
Following their victory, striker Lukas Podolski said: "After the two defeats against Manchester City and Chelsea, the atmosphere was not so good, but now we have won 5-1 and we look to the next game."
Arsenal captain Thomas Vermaelen is doubtful for the trip to the south coast after twisting his ankle in the win against the Hammers. There is good news on the horizon for the Gunners, however, with midfielder Abou Diaby in contention for a start as his long term rehabilitation continues after a thigh injury.
Fifth-tier side Macclesfield Town are seeking a major upset as they host top flight Wigan Athletic. The Silkmen have already defeated one Goliath this season having beaten Cardiff City 2-1 in the third round. A victory for the Cheshire side would make them only the seventh non-league side to get into the fifth round of the competition since Sutton United beat Coventry in 1989.
Macclesfield midfielder John Paul Kissock said: "I love Wigan and I love the style of football Roberto Martinez plays, but they are the ones with everything to lose on Saturday. They are not massive compared to Manchester United or Manchester City but they are a Premier League club. It is a derby and it is a sell-out. "
The match between Norwich City and Luton Town is another potential game for a giant-killing. Canaries manager Chris Hughton is not taking the clash lightly and said: "The squad will be a strong squad of players that have all been involved in the Premier League this season."
Hughton is looking to get his side back to winning ways: "We've bounced back from defeats before and now we want to see a reaction against Luton."
Millwall take on Aston Villa tomorrow night, while Sunday's games feature Leeds United at home to Tottenham Hotspur, Chelsea travel to Brentford, while League One rivals Oldham will host last season's finalists Liverpool.
Elsewhere, Bolton Wanderers host Everton and MK Dons will travel to Queens Park Rangers. There are all-Championship affairs between Derby County and Blackburn Rovers, Hull City and Barnsley, and Huddersfield Town - who sacked manager Simon Grayson today - and Leicester City.