Reigning European champions Chelsea will face Sparta Prague in the last 32 of the UEFA Europa League.
The Blues, who failed to make the knockout stages of the top-tier European competition, will start their bid to become only the fourth club after Juventus, Ajax and Bayern Munich to win all of the major European trophies as they bid to usurp defending champions Atletico Madrid.
Tottenham will take on Ligue 1 side Lyon, starting with a home tie on 14 February, while Liverpool face Russian champions Zenit St Petersburg and Newcastle take on Ukraine's Metalist Kharkiv.
Tottenham general secretary Darren Eales expects a tough clash with Ligue 1's Lyon over the two legs. "It's a tough draw and this is the first time in nine years they've not been in the Champions League," Eales told Sky Sports News.
"There are a lot of tough teams in the draw. We can ask Hugo [Lloris, Tottenham's former Lyon goalkeeper] the way to go and I think he will be excited about the chance to go back to his old team and play there.
"If we do get Inter if we do get through, two years ago in the Champions League when Gareth Bale got that wonderful hat-trick - that's an exciting game but we have to think about Lyon first."
BATE Borisov v Fenerbahce
Inter Milan v Cluj
Levante v Olympiakos
Zenit St Petersburg v Liverpool
Dynamo Kiev v FC Bordeaux
Bayer Leverkusen v Benfica
Newcastle v FC Metalist Kharkiv
Stuttgart v Genk
Atletico Madrid v Rubin Kazan
Ajax v Steaua Bucharest
FC Basel v Dnipro
Anzhi Makhachkala v Hannover
Sparta Prague v Chelsea
Borussia Monchengladbach v Lazio
Tottenham v Lyon
Napoli v Plzen
Napoli or Viktoria Plzen v BATE Borisov or Fenerbache
Leverkusen or Benfica v Dynamo Kiev or Bordeaux
Anzhi Makhachkala or Hannover v Newcastle or Metalist Kharkiv
Stuttgart or Genk v Monchengladbach or Lazio
Tottenham or Lyon v Inter Milan or Cluj
Levante or Olympiakos v Atletico Madrid or Rubin Kazan
Basel or Dnipro v Zenit St Petersburg or Liverpool
Ajax or Steaua Bucharest v Sparta Prague or Chelsea