Ecuadorian champions Deportivo Quito made it into the Copa Sudamericana round of 16 with a 3-1 away win over Aurora in Bolivia.
The 5-2 aggregate win means Ruben Insua's Deportivo Quito will play Argentinian side Tigre in the next round of the South American tournament.
Argentinian forward Julio-Maximiliano Bevacqua put the Ecuadorian side ahead in the 14th minute following good work by Alex Bolanos.
Luis Checa doubled the lead after 35 minutes when Isaac Mina headed down a Luis Saritama corner kick.
Aurora were unable to recover, especially after Bevacqua made it 3-0 on the hour, before Pablo Olmedo reduced the deficit four minutes later with a header.
Deportivo Quito's fellow Ecuadorian side Liga de Loja eliminated Uruguayan giants Nacional to mark their first Copa Sudamericana appearance.
Liga de Loja won 2-1 to go through on away goals after drawing the tie 2-2 on aggregate.
Liga de Loja took the lead after 20 minutes as Johnny Uchuari headed in from a Carlos Feraud free-kick.
Nacional equalised three minutes later as Adrian Luna converted a cross from Adrian Romero.
With twelve minutes remaining Walter Calderon headed Armando Gomez's long pass home to secure the win and Liga de Loja's progress.
Liga de Loja defender Arnaldo Vera told Fox Sports: "This is the prize for good football. We were sure we were able to make history because we have good players and proved we can reach higher positions."
Liga de Loja will now play Brazilian giants Sao Paulo.
Universidad Catolica advanced thanks to away goals as they lost 3-1 to hosts Tolima in Columbia.
The Chilean side, who won 2-0 in the first leg, conceded three times but had a goal from Tomas Costa which secured their progress to face Atletico Goianiense of Brazil.
Felix Noguera put Tolima ahead in the 32nd minute and Gerardo Vallejo doubled the advantage three minutes before half-time. Robin Ramirez added a third three minutes after the break. Costa's goal came only five minutes later.
Goalkeeper Cristopher Toselli told Fox Sports: "If we keep making the mistakes we made tonight, we'll quit the tournament soon. We suffered too much.
"The positive point is the qualification, but only that. We are not happy by our football form."
Ecuadorian side Emelec drew 0-0 with Paraguayan giants Olimpia and went through thanks to a 1-0 away win in the first leg.
Emelec meet reigning Copa Sudamericana champions Universidad de Chile in the next round.