USA midfielder Jose Torres underwent surgery on Wednesday to repair a broken bone on the outside of his left foot and will be sidelined for at least two months.
Torres' Mexican club, Pachuca, set the return timetable for the 23-year-old Texan after the operation on his fifth left metatarsal. New USA coach Jurgen Klinsmann, still searching for his first victory after three matches in the job, has started Torres in all three matches since taking over the squad on 29 July.
The loss of Torres comes a day after USA midfielder Stuart Holden returned to the Bolton line-up in a 2-0 victory against Aston Villa. Holden missed six months with a knee injury after a tackle by Manchester United's Jonny Evans.
Klinsmann will guide his team in two more home friendly matches against 2010 FIFA World Cup™ sides next month, facing Honduras on 8 October at Miami and Ecuador on 11 October in Harrison, New Jersey, as he looks to evaluate talent ahead of next year's Brazil 2014 qualifiers.
"We want to expose the team to as many styles as possible, and we know the quality of Ecuador," Klinsmann said.
USA have two wins and four draws from ten matches against Ecuador, but have won their two most recent meetings, the last a 3-1 triumph in Tampa in 2007. The USA's all-time record against Honduras is 11 wins, three draws and three defeats.
Under Klinsmann, the US drew 1-1 with Mexico last month in Philadelphia, lost 1-0 to Costa Rica in Los Angeles earlier this month and then fell 1-0 to Belgium in Brussels.