Benfica are favourites to advance to the UEFA Champions League group stage after coming away from their play-off first-leg match against FC Twente with a 2-2 draw.
Jorge Jesus's side were under the cosh early on, and fell behind just six minutes into the match when Luuk de Jong fired home from the edge of the area.
However, the Portuguese giants responded well, with Paraguayan striker Oscar Cardozo equalising from distance after 20 minutes before Nolito finished off a fine move inspired by Axel Witsel to give Benfica the lead headed into the break.
The concession of those goals highlighted the Dutch Cup holders' defensive weaknesses, but the introduction of Marc Janko in attack after half-time saw a more threatening display from the Eredivisie club.
There were only ten minutes remaining when Bryan Ruiz headed past Artur to square the tie on the night, although the away goals leave Benfica in a strong position ahead of next Wednesday's return in Lisbon.