Holders Schalke thrashed tiny FC Teningen 11-1 to take their place in the second round of the German DFB-Pokal.
Teningen ply their trade in the seventh tier of the German game, and they were no match for Ralf Rangnick's side, for whom Klaas-Jan Huntelaar scored four times.
Raul, Lewis Holtby and Mario Gavranovic all added doubles, with the Greek Kyriakos Papadopoulos completing the scoring.
Hannover, Hertha Berlin, Hoffenheim, Mainz and Cologne were other top-flight clubs to win today, but Freiburg were sent packing by Unterhaching, a third division club from the Munich suburbs.
Freiburg's defeat makes them the fourth Bundesliga side to be eliminated at the first hurdle, after Bayer Leverkusen, Werder Bremen and Wolfsburg were all knocked out earlier in the weekend.
Champions Borussia Dortmund were comfortable winners at third division Sandhausen on Saturday, while Bayern Munich take on Eintracht Braunschweig on Monday.