The 26-year-old forward netted an incredible 53 goals in 54 appearances for Real Madrid this season, including a record 40 in the league, but missed Portugal's recent friendlies with Finland and Chile through injury.
Norway lead Portugal by three points at the top of Group H, and with only the top side guaranteed a place at next year's finals in Poland and Ukraine, Ronaldo and company can scarcely afford a setback against Egil Olsen's men.
"The objective is to win and go top of the group," said centre-back Bruno Alves. "Norway are a strong team, but we are preparing very well and in the end we will win."
An error from goalkeeper Eduardo gifted Erik Huseklepp the only goal of the game when the sides last met in Oslo in September, in what became Carlos Queiroz's last game in charge of Portugal.
His replacement, Paulo Bento, subsequently oversaw back-to-back 3-1 defeats of both Denmark and Iceland in October that set Portugal's qualifying campaign back on track.
A magisterial 4-0 thrashing of world champions and Iberian rivals Spain in November, meanwhile, went some way towards dissipating memories of the embarrassing 4-4 draw with Cyprus in Portugal's first qualifying match.
"In my opinion, Portugal are the world's best national team at the moment," said Norway coach Olsen. "They are the favourites, but I am optimistic. We can take a point, and even win. Portugal have to win against us, and that may be to our advantage."