Die Nationalelf host the South Americans in Sinsheim on 28 May in a re-match of last year's third-place play-off at South Africa 2010 which Germany won 3-2.
Dortmund were crowned German champions on Saturday when they beat Nuremberg 2-0, but Low has said he will not select the bulk of the Borussia team against the South Americans.
"There will be no Borussia Deutschland -- that is going too far," said Low. "There can sometimes be an advantage to selecting a block of players from the same club, but the majority of the national squad have been together for a long time and the team knows each other well."
Dortmund's success has come after impressive performances from young stars Mario Goetze, 18, Mats Hummels, 22, Sven Bender, 22, Kevin Grosskreutz, 22, and Marcel Schmelzer, 23, who have all played for Germany this season.
Dortmund's youngsters have impressed the senior coach during their time in the Germany squad this season.
"They are clearly highly trained at Dortmund, both in theory and practice, they are good prospects and now it is important they get some international experience in the Champions League," said Low.
But Low said they still have some way to develop before they can challenge for first-choice places at UEFA EURO 2012 and the next FIFA World Cup to be held in Brazil in 2014.
"The young players need to progress further in Dortmund, because the scale they are measured at will always be the major tournaments," he continued. "They have to prove they can play well at this high level."
Germany are currently top of their qualifying group and are set to face Austria in Vienna on 3 June and Azerbaijan in Baku on 7 June in UEFA EURO 2012 qualifiers.