The Americans have beaten the seven-time Africa Cup winners in their only prior meetings, the most recent a 3-0 triumph over the Pharoahs at the 2009 FIFA Confederations Cup in South Africa.
The other US triumph also came at a neutral venue, a 3-1 victory at Seoul in 1987. USA coach Bob Bradley was excited about the chance for the American side to play a first-ever match in Egypt ahead of next June's Gold Cup tournament, the North American continental championship.
"Egypt is an extremely talented and competitive team," Bradley said. "Their performances in the Confederations Cup and the Africa Cup of Nations have demonstrated their ability to challenge the top teams in the world.
"To play against the champions of Africa in what will be a fantastic environment in Cairo is a great opportunity."
The Americans open their 2011 campaign on 22 January against Chile; the game will be played in Los Angeles.
The Pharoahs, currently ranked 10th in the world, went undefeated to win this year's Africa Cup of Nations with Mohamed Nagy scoring five goals and captain Ahmed Hassan being named player of the tournament.
However, unlike the United States, Egypt failed to qualify for the 2010 FIFA World Cup™, losing in a play-off to bitter rivals Algeria.