Avai missed the opportunity to climb into third place in the Brasileirao by losing 4-1 at Guarani.
The hosts raced into a two-goal lead, with Renan netting after nine minutes and Ricardo Chavier doubling the advantage two minutes later.
Robson pulled one back from the penalty spot on 13 minutes, but Guarani restored their two-goal lead after 34 minutes through Mazola, before Fabao added a 70th-minute fourth to seal victory.
The standings are led by Fluminense, with Guarani eight points behind in ninth, one point behind sixth-placed Avai.
Botafogo are eighth in the table following a 3-0 defeat of Atletico Mineiro.
Maicosuel and Somalia put the hosts 2-0 up before the interval, and German Herrera converted a 69th-minute penalty to cap Botafogo's fourth win of the season.