The biennial North American championship will be played entirely on US soil for the sixth time in eight stagings, starting 6 June in Miami and concluding 24 June in Chicago.
Four-time Gold Cup champion Mexico went into Group C with 2005 runner-up Panama, Honduras and US political rival Cuba. Costa Rica, Haiti, Guadeloupe and Canada were put into Group A while the Americans and their foes are in Group B.
"The Gold Cup is very important," US interim coach Bob Bradley said. "Defending the title in the first big tournament I'm coaching is very, very important."
New Mexican coach Hugo Sanchez is hungry to topple the US squad and have his club capture the throne as it last did in 2003.
"This is a new era for the Mexican team and I am convinced we are going to make history," Sanchez said. "But to start this history that will be so beautiful, we have to win the Gold Cup."