Roma's John Arne Riise is facing up to 25 days on the sidelines, after straining his knee against Palermo last weekend.
After a slow start to life in Italy, following his transfer from Liverpool in the summer, the Norwegian has managed to cement the left-back spot in coach Luciano Spalletti's team.
Roma have been on the rise recently following a disastrous start to their campaign, when they won only two of their first ten matches.
But nine wins in the following 12 games has brought them up into UEFA Champions League contention.
Roma-Genoa, Tottenham Hotspur-Arsenal and Porto-Benfica are among the matches on the FIFA World Leagues Predictor's Round 22 menu. If you haven't already, be sure to sign up and take a shot at winning this weekend's prize.