Trabzonspor claimed a 3-1 victory at Istanbul Buyuksehir to open up an eight-point gap at the top of the Super Lig.
Burak Yilmaz opened the scoring after two minutes only to see the goal cancelled out by Herve Tum five minutes before the interval.
But Yilmaz restored Trabzonspor's lead with a 74th-minute penalty and Umut Bulut made certain of the points 14 minutes from time, with the hosts finishing the match a man down following the late dismissal of Ekrem Eksioglu.
Fenerbahce missed out on second spot with a 2-1 defeat at Ankaragucu.
Stanislav Sestak scored both goals for the home side with Mamadou Niang netting a late consolation for Fener.
Sivasspor overcame the early dismissal of Sedat Bayrak to climb out of the bottom three with a 1-0 win over Konyaspor, courtesy of Erman Kilic's second-half strike.
Goals from Julio Cesar and Ahmet Ari earned Gaziantepspor a 2-0 victory over Kayserispor.