Toluca and Pachuca advanced to the Clausura semi-finals with victories on Sunday.
Toluca beat Tijuana 3-1 to go through by the same score on aggregate, while Pachuca claimed a 4-2 away win at Unam Pumas after a goalless first leg in their tie.
Hernan Pellerano then collected a second booking for Tijuana eight minutes from time, and Edgar Benitez capitalised to make the game safe for Toluca.
Enner Valencia's hat-trick sent Pachuca through, but only after they had twice conceded the lead.
Valencia scored in the 12th and 25th minutes, but saw those goals cancelled out by Efrain Velarde and Jose Van Rankin.
However, Valencia completed his hat-trick in the 47th minute before Hugo Rodrigues wrapped it up soon after.