Raffaele Palladino has become the latest Genoa player to be sidelined by injury.
The 26-year-old striker sustained a left thigh problem during Sunday's 1-0 victory over Catania and will be out of action for four weeks.
I Grifoni already have five players unavailable.
Frontmen Bosko Jankovic and Rodrigo Palacio and midfield duo Houssine Kharja and Miguel Veloso will only to return to training in mid-November, while forward Giuseppe Sculli is out until the new year.
It is bad news for coach Gian Piero Gasperini, whose team host Serie A champions Inter Milan on Friday before travelling to Palermo on 7 November.