The leading contenders in the continent's major championship races endured contrasting fortunes at weekend. While Liverpool, Chelsea and Bayern Munich all limbered up for this week's UEFA Champions League group openers with fine victories, Manchester United, Roma and Barcelona will be fretting after their lacklustre performances. FIFA.com reviews all the latest domestic news from the top five leagues and beyond.
Ligue 1: Lyon back on top
The first big clash of the French season ended with honours even as Bordeaux and Olympique Marseille played out a 1-1 draw. In an entertaining game, l'OM struck first when Bakary Kone put them ahead after only two minutes. Laurent Blanc's side reacted well, however, and claimed a share of the points with Marouane Chamakh's equaliser on 24 minutes.
Title holders Olympique Lyonnais took to the top of the table after staging a thrilling comeback at home to Nice. 2-0 down after only 20 minutes, Les Gones were indebted to a remarkable performance from Juninho Pernambucano, who hauled his side level with two spectacular free-kicks. The fightback was completed when Karim Benzema stroked home a penalty in the fourth minute of injury time. The win takes Lyon to 13 points, two clear of Marseille in second.
Newly promoted Grenoble maintained their fine start to the season after earning a 1-1 draw at Valenciennes and lie fourth, just three points behind the leaders. One place above them on goal difference are PSG, who overcame Nantes thanks to Mateja Kezman's penalty seven minutes in.
Top three: Lyon (13 points), Marseille (11 points), PSG (10 points)
Bottom three: Saint-Etienne (3 points), Sochaux (2 points), Nantes (1 point)
Top scorers: Karim Benzema (5 goals), Fernando Cavenaghi, Bakari Kone (3 goals)
Weekend stat: Six of the seven goals Rennes have conceded this season have come in the first half.
Bundesliga: Hamburg out front, Bayern on track
After falling two goals behind in the opening half hour at home to Bayer Leverkusen, Hamburg surged back with goals from Paolo Guerrero, Ivica Olic and Mladen Petric to claim an unlikely win that took them to the top of the table.
Hot on their heels, just two points behind, are Bayern Munich, Schalke 04 and Borussia Dortmund, who started the day in first place. The Bavarians continued their ominous climb up the table after downing new boys Cologne 3-0, recording their first clean sheet of the season. Italy striker Luca Toni was the architect of the win, scoring twice and laying on a third.
The day's big game between Borussia Dortmund and local rivals Schalke 04 lived up to all expectations. Schalke seemed to be out of sight when they led 3-0 with a little over 20 minutes remaining. Stung into action, the hosts fought back and completed a magnificent comeback when two-goal hero Alexander Frei converted a late penalty.
Top three: Hamburg (10 pts), Bayern Munich, Schalke 04 (8)
Bottom three: Eintracht Frankfurt, Arminia Bielefeld (2), Energie Cottbus (1)
Top scorers: Artur Wichniarek, Vedad Ibisevic (4 goals), Luca Toni (3)
Weekend stat: 22 second-half minutes were all Borussia Dortmund needed to wipe out Schalke 04's 3-0 lead in Saturday's Ruhr derby.
Premier League: Liverpool and Chelsea impress
Liverpool's 2-1 defeat of Manchester United was their first over Alex Ferguson's men at Anfield since 4 November 2001 and ensured they stayed level with Chelsea at the summit. Ryan Babel scored the Reds' winner 11 minutes from time, condemning United to their first defeat of the season.
In the other main attraction of the day Chelsea came away from Eastlands with a 3-1 win over over Manchester City. After recovering from the shock of an early goal from who else but Robinho, the Blues hit back through Ricardo Carvalho, Frank Lampard and Nicolas Anelka.
An Emmanuel Adebayor hat-trick helped Arsenal to a commanding 4-0 win at Blackburn Rovers. The Gunners now lie third, just a point adrift of the leading duo.
Sitting just behind them in fourth are early-season revelations Hull City, who picked up a 2-1 win at Newcastle thanks to goals from Marlon King either side of half-time.
Top three: Chelsea, Liverpool (10 pts), Arsenal (9)
Bottom three: Blackburn Rovers (4), Stoke City (3), Tottenham Hotspur (1)
Top scorers: Jermain Defoe, Amr Zaki (4 goals), Robin van Persie (3)
Weekend stat: At the age of just 16 years and 256 days, Arsenal tyro Jack Wilshere became the youngest ever player to appear in an English Premier League match when he came on for Robin van Persie in the 83rd minute of Saturday's match at Blackburn.
Serie A: Slip-ups for AC Milan and Roma
Inter Milan were made to work hard by Catania on Saturday before emerging 2-1 victors at San Siro. Reduced to ten men when Sulley Muntari was sent off on the stroke of half-time, Inter received an unexpected helping hand from Christian Terlizzi, who put through his own goal just after the restart to give the Nerrazzuri the points.
Roma, still without captain and talisman Francesco Totti, had a day to forget when they slumped to a 3-1 defeat at Palermo. Julio Baptista put the visitors ahead only for the Sicilians to roar back with a brace from Fabrizio Miccoli and an Edison Cavani goal late on.
AC Milan's travails continued on Sunday when they went down to a second consecutive 2-0 defeat, this time away to Sampdoria. Elsewhere, Fiorentina lost 2-1 at Napoli, while Juventus beat Udinese 1-0 in Sunday's late game courtesy of an Amauri goal midway through the second half.
Top three: Lazio, Atalanta (6 pts), Torino (4)
Bottom three: Sampdoria (1), AC Milan, Cagliari (0)
Top scorers: Mauro Zarate (3 goals), Goran Pandev, Antonio di Natale (2)
Weekend stat: With just two games gone, Lazio lead the way in Italy for the first time in five seasons. The Romans have now won their last five Serie A matches, having ended last season with three wins on the bounce.
La Liga: Barcelona held, Real Madrid stutter
Barcelona are experiencing a torrid start to the season. After losing to Numancia on day one, the Catalans dropped two points at home to Racing Santander on Saturday evening after Pereira Rodriguez cancelled out Lionel Messi's 73rd-minute spot-kick.
Sevilla and Sporting Gijon served up a seven-goal thriller the same night, sharing six goals in the first half before Frederic Kanoute sealed the points for the Andalusians.
Villarreal earned a vital 1-0 win at home to Deportivo La Coruna on Sunday, while Real Madrid recovered from a shaky start to see off Numancia 4-3. The champions looked far from convincing, however, and have given their fans plenty to worry about ahead of their opening UEFA Champions League encounter. In the day's final match Valencia came from behind twice to earn a 2-2 draw at Almeria.
Top three: Espanyol (6 pts), Sevilla, Getafe (4)
Bottom three: Mallorca, Malaga (1), Sporting Gijon (0)
Top scorers: Mate Bilic (3 goals), Frederic Kanoute, Diego Forlan (2)
Weekend stat: Latching on to a pass from Ruud van Nistelrooy, Guti saw his left-foot drive deflect off a Numancia defender and into the back of the net for Real Madrid's 5000th goal in the Spanish league.
It was a good weekend for the top three in Belgium, with leaders Mouscron earning a 4-2 win at home to Gent, Anderlecht seeing off Mons 2-1 and Standard Liege downing Courtrai 2-0.
In Scotland, Rangers continued to set a fast pace after overcoming Kilmarnock 2-1. Celtic won 4-2 at Motherwell to stay three points behind.
The big three in Netherlands also won. PSV Eindhoven and Feyenoord registered respective 1-0 and 5-0 wins against Sparta Rotterdam and Volendam on Saturday, with Ajax following suit on Sunday when they edged out Roda 1-0.