Leverkusen are one of only two teams to have beaten the league leaders in the first half of the season.ictory at the BayArena would be a huge step towards a first league crown since 2002 for the Westphalians.
"We are delighted to get back in action and have high hopes for the second half of the season," said Klopp. "It could not get any better than to start off with such a game - it is going to be great fun."
Fun would not be the word to describe Steve McClaren's first six months in charge of Wolfsburg and, despite being given a vote of confidence before Christmas, the first Englishman to coach in the Bundesliga knows he is skating on thin ice.
His first challenge of 2011 comes against defending champions Bayern Munich on Saturday, and he will have to master it without Edin Dzeko after the Bosnian was sold to Manchester City earlier this month.
"Of course it is a sporting loss for us and of course it is also a risk, but we weighed it up carefully," said Wolfsburg's managing director Dieter Hoeness. "Edin is a fantastic player - one of the best strikers around. He has what it takes to become a world star, but he has got to be fully focused to become that and, recently, he wasn't (fully focused) with us. The sale of Edin is a clear sign of a revolution, but in no way a sign that we have given up on the season."
Elsewhere on Saturday, Werder Bremen host Hoffenheim and St Pauli entertain Freiburg while Schalke and Hamburg meet at the Arena AufSchalke. Sunday's games see Hannover travel to Eintracht Frankfurt as well as Kaiserslautern's clash with Cologne, who are in the midst of a player crisis due to a flu virus.
Borussia Monchengladbach start the new year with a trip to fellow strugglers Nurnberg on Saturday while 17th-placed Stuttgart host second-placed Mainz.