A penalty saw Lille claim their first win of the Ligue 1 season with Divock Origi's spot-kick sealing a 1-0 victory against newly-promoted Caen.
Rene Girard's side finished third last season to qualify for the UEFA Champions League, their success based first and foremost on a watertight defence. And they have yet to concede a goal in the new Ligue 1 campaign, following up a 0-0 draw at home to Metz on the opening day by edging out another of the division's new boys to set themselves up for next Wednesday's Champions League play-off first leg at home to Portuguese giants FC Porto.
The game, played 160 kilometres away from Caen in Le Mans because the Normandy side's own stadium is being used for the World Equestrian Games, appeared to be heading for a stalemate until a penalty was awarded in the 69th minute.
Origi stepped up to score from 12 yards, and Lille held on as Rio Mavuba cleared a last-minute Fode Koita header off the line.
That made it a frustrating evening for Caen, who marked their return to Ligue 1 after a two-year absence by beating Evian 3-0 last weekend but lost influential striker Mathieu Duhamel to a leg injury early in the second half.
On Saturday, David Luiz could make his debut for Paris Saint-Germain when the champions entertain Bastia, who are now coached by ex-PSG captain and assistant boss Claude Makelele.
Last season's runners-up Monaco will look to bounce back from an opening-day loss against Lorient when they go to Bordeaux on Sunday evening.