Holders Saint-Etienne have been drawn away to Paris Saint-Germain in the headline clash of the last 16 of the Coupe de la Ligue.
Saint-Etienne defeated the Ligue 1 champions on their way to lifting the silverware last season and will have to pull off the same feat if they are to successfully defend their crown.
The clash is one of six all-Ligue 1 encounters, while Ligue 2 representation in the quarter-finals is assured after Troyes were drawn against Tours.
The last-16 ties will be played on 17-18 December.
Draw in full:
Lyon v Reims
Nantes v Auxerre
Paris Saint-Germain v Saint-Etienne
Troyes v Tours
Marseille v Toulouse
Evian v Bastia
Nice v Sochaux
Rennes v Bordeaux