Lille were indebted to a superb display from veteran goalkeeper Mickael Landreau and a debut goal by young full-back Djibril Sidibe after they drew 2-2 at Nice.
Sidibe, 20, claimed a 59th-minute equaliser after the hosts had come from behind to lead, while Landreau produced a string of jaw-dropping saves to keep the 2011 champions in the game.
With Lille having suffered a damaging 1-0 defeat at FC Copenhagen in the first leg of their UEFA Champions League play-off on Tuesday, Sidibe's goal enabled them to avoid a second setback in the space of four days.
Lille coach Rudi Garcia made six changes to the team that fell in Copenhagen and Nice made all the early running, with Landreau intervening smartly to repel efforts from Alexy Bosetti, Franck Dja Djedje and Nemanja Pejcinovic.
The visitors took the lead against the run of play in the 39th minute, with Florent Balmont intercepting Renato Civelli's pass and freeing Dimitri Payet to beat Joris Delle with a crisp left-foot shot.
Sidibe saves a draw for Lille
However, Pejcinovic cancelled out the visitors' advantage shortly before half-time and Claude Puel men's went ahead in the 55th minute after Eric Bautheac capped a slick move with a shot that found the top-right corner.
Sidibe's swift response ensured that Lille did not trail for long. Having collected the ball just outside the Nice box, the close-season signing from Troyes darted through the home defence before rolling the ball past Delle.
Thereafter, it was Landreau's time to shine. The 33-year-old showed pin-sharp reflexes to parry Civelli's header in the 66th minute and then did brilliantly to adjust his feet in order to claw away a deflected free-kick from Bautheac.
The draw left Lille in fifth place, two points behind Lyon, who moved to the top of the standings after a ferocious Michel Bastos free-kick earned them a 1-1 draw at Evian on Friday.