Breton top flight outfits Rennes and Lorient endured mixed fortunes on Tuesday as the former crashed out of the French Cup while their neighbours reached the quarter-finals.
In a thrilling encounter, Rennes slumped to a 4-3 home loss to second division former European Cup finalists Reims despite Abdoulrazak Boukari giving them the lead. Romain Amalfitano swiftly levelled and Julien Toudic and Gaetan Courtet completed the turnabout before Jerome Leroy netted twice in quick succession only then to miss a spot-kick to bring extra time.
There was still time for Yacine Brahimi to miss another penalty for the hosts - Kossi Agassa again performing heroics in the Reims goal - before Mickael Tacalfred drove in low for the winner as Rennes became the 14th first tier side to exit the competition prematurely.
They could still have pulled out a result in the closing stages but Brahimi hit the post and Romain Danze had an effort chalked off after the ball was ruled out of play during the build-up, as Reims clung on to knock out another elite side after Montpellier in the Round of 64.
Lorient scored an emphatic 3-0 win over second tier Metz 3-0, all the goals coming in the second half including a brace from Kevin Gameiro.
Second division Angers also moved into the last eight for the first time in 35 years. Having put out first division sides in the shape of Valenciennes and then Bordeaux in quick succession, Angers thanked goals from Gaetan Charbonnier direct from a corner and Feredory Dore's injury-time clincher as they defeated third division Strasbourg 2-0.
On Wednesday, fifth division amateurs Chambery will be out to add Sochaux to their list of scalps after knocking out Monaco and Brest while Paris Saint Germain must avoid any slip-ups at fourth tier Martigues and Nice likewise take on fourth tier opposition in Drancy.