Bordeaux defender Marc Planus faces another six weeks out of action due to the knee injury which has sidelined him for much of the season.
The 28-year-old has played just half a game in Ligue 1 this season, in last month's 2-0 defeat to shock table-toppers Brest.
And a scan on Tuesday indicated he is unlikely to return to contention until January, with Girondins coach Jean Tigana telling L'Equipe: "It's serious."
His absence is offset to a degree by the return of Lamine Sane, who told the club's official website: "I had a little sprain but I have now recovered.
"Everything is going well. I feel good and I think I will have recovered for Saturday. After that, it depends on the coach's choice."
Brazilian Carlos Henrique iis another defender to have suffered from injuries this season, and Sane admits the unsettled nature of Bordeaux's defensive unit has been a hindrance.
"We have to make do with injuries and suspensions, we have been unable to have a settled defense," he said.
"It's true that we have often found ourselves in difficulties, but it happens. We must show the coach that he can have confidence in us by showing more defensive strength, individually and collectively."