Alex Ferguson lit the fuse on a potentially explosive showdown with Manchester City as the Manchester United manager claimed a victory at Eastlands would be one of his club's greatest ever results.
For the first time in 44 years, City will go into the Manchester derby as reigning English champions, but the bragging rights from pipping United to the title on the final day of last season will count for nothing if Ferguson's side inflict a first league defeat of the season on Roberto Mancini's men at Eastlands on Sunday.
United are three points clear of second placed City at the top of the Premier League and the prospect of allowing their bitter rivals to extend that lead is certain to provoke a ferocious response from the hosts after their exit from the UEFA Champions League in midweek.
With United showing alarming defensive frailties in recent weeks, encapsulated by a chaotic 4-3 win at Reading last week, Ferguson knows it won't be easy to subdue City, especially as the Blues have a formidable record on their home turf.
City haven't lost a league home game since Everton won at Eastlands in December 2010 and they can also take confidence from a pair of league victories over their bitter rivals last season.
In the circumstances, Ferguson believes a derby victory would rank as one of the all-time great United triumphs.
"If we win (on Sunday) it will be one of our best ever results. They are a really good, powerful team with massive players," Ferguson said.
"It won't be easy and if we defend like we did at Reading we'll be in trouble. The important thing for us is to take lessons from the mistakes we're making and do something about it. We need to find a solution."
Mancini faced renewed questions about his future after City's latest European flop and a defeat to United would only add to the pressure on the Italian.
Reports of Pep Guardiola or Jose Mourinho replacing him at the end of the season will make unpleasant reading and, while Mancini is convinced he will be given time to get his spluttering team back on track, even he admits his players need to raise their game.
"It's clear the season isn't finished. We have the Premier League and FA Cup to go for, but we must work more now. What we're doing is not enough," Mancini said.
"I don't feel any pressure. I'm disappointed because we went out of the Champions League and I'm disappointed for the club because they deserve to go through and for our players, who deserve to play on that stage."
The theme of managers under pressure runs through the rest of the weekend's programme at both ends of the table.
Arsenal boss Arsene Wenger has been under fire of late and another negative result against West Bromwich Albion on Saturday would trigger more bile from the growing number of critics among the club's previously loyal fanbase.
Wenger's team are on a miserable run of two wins from their last nine matches in all competitions and Spanish midfielder Mikel Arteta, is well aware that a victory over West Brom is essential to ease the sense of crisis enveloping the Gunners.
"We want the fans to stay behind us but the fans need us to be on top of our form to get that excitement," he said. "We have to give them something now and they will respond, because they love Arsenal as much as we do."
At the Stadium of Light on Saturday, both Chelsea interim manager Rafael Benitez and Sunderland boss Martin O'Neill are in desperate need of a morale-boosting victory.
Benitez has yet to win a league match since replacing Roberto Di Matteo, while O'Neill has presided over a woeful run of two wins from their last 22 league games.
Aston Villa boss Paul Lambert, whose lowly side host Stoke, and Nigel Adkins, whose Southampton team take on fellow strugglers Reading, could also do with three points to keep the critics at bay.
English Premier League fixtures
Arsenal v West Brom
Aston Villa v Stoke
Southampton v Reading
Sunderland v Chelsea
Swansea v Norwich
Wigan v QPR
Everton v Tottenham
Manchester City v Manchester Utd
West Ham v Liverpool
Fulham v Newcastle