Bolivian giants The Strongest made it into the Copa Libertadores round-of-16 with a 2-1 home triumph over Brazil's Atletico Paranaense on Tuesday.
The victory placed the La Paz side in the second spot of Group 1 on 10 points, while Paranaense went down to third on 9 and become eliminated.
An own goal by Manoel put The Strongest ahead but Adriano levelled seconds before half-time following a Marcelo pass. However, Nelvin Soliz netted the winner nine minutes after the break.
Already-qualified Velez Sarsfield of Argentina won 1-0 over Peru's Universitario. Roberto Nanni recovered from a missed penalty in the first half and netted the winner and Velez finished on top of Group 1 on 15 points.
They have the possibility to be the best team in the group stage campaign if Mexico's Santos Laguna do not beat Arsenal in Argentina on Thursday, which means they would play the second legs of all the play-off rounds at home. Nanni scored seven minutes after the interval after being assisted by Ariel Cabral.
Velez coach Jose Oscar Flores, who won the Libertadores as a Velez player in 1994, told Fox Sports: "We achieved the goal. I'm very happy. The guys played this game very seriously and this is a deserved win."
An own goal by Luis Payares and contributions by Daniel Gonzalez Guiza and Julio Dos Santos (penalty) gave Cerro Porteno the win, while Christian Marrugo and Carlos Rivas scored for the visitors.
Finally in Chile, Lanus keeper Agustin Marchesin saved a penalty and a number of other opportunities in a goalless draw against hosts O'Higgins.